Volume :
3
Issue :
3
Abstract :
To develop two simple, accurate, precise, reproducible and economical UV spectroscopic methods (A & B) for simultaneous estimation of Ciprofloxacin and Tinidazole in tablet dosage form. Method A employs solving of simultaneous equations based on the measurement of absorbance at two wavelengths, 272 nm and 365 nm which are the λmax of Ciprofloxacin and Tinidazole respectively in 0.1N NaOH. Method B is based on the principle of Q-Analysis where in the absorbance was measured at 299 nm (isoabsorptive point) and 277 nm (λmax of Ciprofloxacin) in 0.1N HCl. Ciprofloxacin and Tinidazole show linearity at all the selected wave lengths and obey Beer’s law in the concentration range of 2-7 μg/mL and 4-24 μg/mL respectively. Recovery studies for Ciprofloxacin and Tinidazole were performed and the percentage recovery for both the drugs was obtained in the range of 98-102% for both methods A&B confirming the accuracy of the proposed method. Both the methods showed good reproducibility and recovery with %RSD