Volume :
2
Issue :
3
Abstract :
Enalapril is a potent ACE inhibitor which is rapidly metabolized in the liver.It is rapidly converted by ester hydrolysis to Enalaprilat on oral administration. It may be used to treat renovascular hypertension, symptomatic congestive heart failure and hyperglycaemia. It may be used alone or in combination with thiazide diuretic. However its absorption is erratic in diabetic patients due to impaired gastric motility so, to overcome this the present study gastric retentive controlled release dosage form of the drug was formulated with different polymers like HPMC K15M, sodium bicarbonate, magnesium stearate, MCC, talc in different ratios. In this direct compression method has been employed to prepare floating matrix tablets. The formulations F1-F12 were formulated and evaluated for various quality control parameters. All the formulations were passed the tests and the results were within limits. From the dissolution data it was evident that formulation F11 was found to be best formulation with maximum % drug release of 99.92 % in 12 hours.