Volume :
1
Issue :
1
Abstract :
The aim of the present study was to develop sustained release formulation of Telmisartan HCl to maintain constant therapeutic levels of the drug for over 12 hrs. Eudragit RL 100, Guar gum and ethyl cellulose were employed as polymers. Telmisartan HCl dose was fixed as 20 mg. Total weight of the tablet was considered as 300 mg. Polymers were used in the concentration of 30, 60 and 90 mg concentration. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F6) showed better and desired drug release pattern i.e., 96.10 % in 12 hours. Optimized formulation drug release was fitted into different drug release kinetics, it followed zero order release kinetics mechanism.