Volume :
2
Issue :
3
Abstract :
Simvastatin is a lipid lowering agent that is derived synthetically from the fermentation of Aspergillus terreus. It is a potent competitive inhibitor of 3-hydroxy-3-methyl glutaryl coenzyme A reductase. It is used to lower cholesterol and triglycerides (types of fats) in the blood. It is also used to lower the risk of stroke, heart attack and other heart complications in people with diabetes and coronary heart disease. Common side effects of simvastatin may include headache, constipation, nausea and stomach pain. The GFDDS of simvastatin were developed in the form tablets comprising of an effervescent agent. The GFDDS of simvastatin prepared from HPMC remained intact and the compactness of the tablets was not affected during the invitro dissolution test.