Volume :
2
Issue :
1
Abstract :
Sumatriptan is a medication used for the treatment of migrane headaches. It is a synthetic drug belonging to the triptan class. Structurally, it is an analog of the naturally occurring neuro-active alkaloids dimethyl tryptamine (DMT), bufotenine, and 5-methoxy-dimethyltryptamine, with an N-methyl sulfonamidomethyl- group at position C-5 on the indole ring. Various approaches have been developed to retain the dosage form in the stomach. Gastric floating drug delivery systems offer numerous advantages over other gastric retention systems. The GFDDS of sumatriptan succinate were developed in the form of tablets comprising of an effervescent agent. The prepared mini tablets were subjected to pre and post compressional parameters and the values were within the prescribed limits. The drug- excipient compatibility studies were performed using FTIR techniques. The effect of different formulation parameters such as concentrations of effervescent agent on floating properties and drug release kinetics were studied and the formulations were optimized. The concentration of the effervescent agent greatly influenced the floating lag time. From the results it can be concluded that F11 with HPMC K100M, and sodium bicarbonate as gas generating agent provides the 99.92 % of drug release up to 12hours. By increasing the concentration of the polymer, decreased dissolution rates were obtained for the all the polymers. The slow rate of polymer hydration and the presence of effervescent agent caused a burst release initially. Hence, all the GFDDS were formulated without addition of the loading dose. Although the release rate mainly depended on the proportion of the polymer, the entrapped gas within the hydrogel also influenced the rate of drug release from the GFDDS. By increasing the proportion of the effervescent agent, the porosity produced by the entrapped gas increased and dissolution rate was increased.