Abstract :
Abstract Emulgel is a combinational formulation consisting of emulsion and gel and the type of combination depends upon the nature of drug so that maximum bioavailability can be achieved. The benefits of Emulgel over the traditional topical administration include thixotropic, greaseless, improved spreadibility, easily removable, biodegradable, emollient, and better convenience. Along with this, high stability and improved shelf life of Emulgel is also encouraging the researchers to develop new products belonging to this class. Currently, the available topical drug administration technologies are able to deliver the hydrophilic drugs only and the inability to deliver the hydrophobic drugs is one of the major limitations for this approach. Dexketoprofen trometamol appears to provide similar analgesic efficacy to COX-2 inhibitors when used to treat acute pain, has a rapid onset of action, is well tolerated, and has an opioid-sparing effect when used as part of a multimodal regimen in the acute pain setting. Emulgel was concluded to be a successful dosage form for topical delivery of drugs. Out of all the prepared formulations, F5 was found to have the best release rate and maximum drug content
Keyword :
Keywords: Cox-2 inhibitor, emulgel, dexketoprofen, spreadibility, permeation