Volume :
2
Issue :
4
Abstract :
Nateglinide is used in the treatment of generalized non insulin dependent diabetes mellitus. Once inside the cell, glucose is metabolized to produce ATP. High concentrations of ATP inhibit ATP-sensitive potassium channels causing membrane depolarization. When extracellular glucose concentrations are low, it causes repolarization. The influx of calcium ions stimulates calcium-dependent exocytosis of insulin granules. Nateglinide increases insulin release by inhibiting ATP-sensitive potassium channels in a glucose-dependent manner. The F4 formulation diffusion exponent n value is in between 1.07 to1.99. F4 gave better-controlled drug release and floating properties in comparison to the other formulations. The release pattern of the F4 formulations was best fitted to Korsmeyer-Peppas model, Higuchi and first-order model. The most probable mechanism for the drug release pattern from the formulation was non-Fickian diffusion or anomalous diffusion.