Design, synthesis, spectral analysis, antibabacterial activity of n-(3-chloro-2-oxo-4-arylazetidin-1-yl)-3 hydroxybenzofuran-2- carboxamide derivatives

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Abstract :

3-hydroxybenzofuran-2-carbohydrazide undergoes facile condensation with aromatic aldehydes to afford the corresponding N-arylidene-3-hydroxybenzofuran-2-carbohydrazide in good yields. Cyclo condensation of compounds with chloro acetyl chloride yields N-(3-chloro-2-oxo-4-arylazetidin-1-yl)-3 hydroxybenzofuran-2- carboxamide. The structures of these compounds were established on the basis of analytical and spectral data. The newly synthesized compounds were evaluated for their antibacterial activity.