Volume :
2
Issue :
3
Abstract :
Inflammation is defined as a localized protective reaction of tissue to irritation, injury, or infection, characterized by pain, redness, swelling, and sometimes loss of function. Several drug molecules with heterocyclic moieties were reported as anti-inflammatory drugs. Chalcones either natural or synthetic and their heterocyclics are known to exhibit various biological activities. Pyrimidines are the parent substances of a large group of heterocyclic compounds and play a vital role in many biological processes and possess various therapeutic activities. The pyrazoline nucleus is a ubiquitous feature of various therapeutically active compounds. Some of the novel molecules with pyrimidine or pyrazoline moiety were reported to possess anti-inflammatory activity. In the present study an attempt is made to synthesize novel pyrimidines and novel pyrazolines from chalcones which provide an easy route of synthesis. All these compounds were characterized by means of their IR, 1H NMR, 13C NMR, and mass spectral data. These compounds were evaluated for antiinflammatory activity by carrageenan induced rat paw oedema model.