Volume :

5

Issue :

1

Abstract :

The Aim of the present study is to design and evaluate fast dissolving Oral thin films (OTF) of Alendronate drug. The bisphosphonate called alendronate used for osteoporosis and several other bone diseases. Sixteen Formulations (F1–F16) of OTF were prepared by casting method using different concentrations of polymer increased tensile strength and folding endurance were improved with more dissolution time. 0.3% and above concentration of polymer showed good physical and rheological properties. Optimized formulation among OTF was an F4 with 1.5% Sodium alginate showing good folding endurance, tensile strength, disintegration time and 98.9% drug release with no casting problem and appearance.