Volume :

2

Issue :

4

Abstract :

Nizatidine effervescent controlled release floating tablets employing three grades of HPMC K4M, HPMC K15M and HPMC K100M in four ratios (1:0.5; 1:1; 1:5 and 1:2) were prepared and evaluated. FTIR, DSC and XRD studies on the formulations showed no interaction of nizatidine with the polymers employed in the study. Most of the tablet formulations showed values within the official limit upon pre and post- compression evaluation. The type of polymer affected the drug release rate and the mechanism. Polymer swelling was crucial in determining the drug release rate flotation. A lesser FLT could be achieved by increasing the concentration and increasing the viscosity grade of the polymer. The optimized formulation (NS6) offered best controlled release along with floating lag time of 1.2 min and total floating time of >14 h. Good stability was observed for 3 months during accelerated stability studies. The optimized formulation NS6 employing nizatidine: HPMC K15M in the ratio of 1:1 showed sufficient release for prolonged period, the dose could be reduced and the possible incomplete absorption of the drug could be avoided.