Abstract :
Combination therapy is gaining high attention in pharmaceutical industry. It provides many advantages
in accuracy of dose and patient compliance, especially in pediatrics. This work aims to formulate successful fixeddose
combination pediatric oral dosage form as orodispersible tablets (ODTs) which contain a combination of
amoxicillin 125 mg as an antibiotic and ibuprofen 100 mg per tablet for the treatment of several pediatric illnesses
that need this combination. Materials and Methods: Design of experiment (DoE) was used to design the best
formula for the proposed combination. The selection of non-active materials based on the improvement of tablet
characteristics, taste, and safety. Then, DoE was used to predict the best combination of additives that give the best
criteria of ODTs. The three responsive factors were wetting time and disintegration time and dissolution of both
drugs taken as 70% of drug is dissolved at or in
Keyword :
Amoxicillin, DOE, fixed combination therapy, ibuprofen, orodispersible tablets, pediatric preparation