Abstract :
Dendritic cells (DCs) are the most powerful APCs in the immune system. Both immunity and immune
tolerance are controlled by the DCs which are at the centre of the immune system. They have a higher ability to
trigger Ag-specific immune responses and promote both adaptive immunity and innate immunity. Therapeutic
immunity against cancer can be targeted by DCs. Treatment of tumours in cancer immunotherapy is harnessed by
the capacity and specificity of the immune system. Autologous Ag-specific T cells are proliferated ex vivo and then
re-infused into patients or through vaccination; that is, the provision of an Ag together with an adjuvant to elicit
therapeutic T cells in vivo. DC vaccine appears to have potential to increase overall survival with minimal
complications. However, still certain problems has to be met during vaccination, such as targeting specific or
associated Ags, adjuvants, clinical status, and the evaluation of the response.
Keyword :
Dendritic Cells, Cancer, Immunity, Vaccine.