Abstract :
Purpose: To study the correlation between choroidal vascularity index, flow pattern and neovascular activity in treatment naive eyes of age related macular degeneration.
Materials and Methods: Cross-sectional analysis of 46 treatment naive eyes diagnosed with exudative age related macular degeneration. All patients underwent spectral domain optical coherence tomography, fluorescein angiography, indocyanine green angiography and OCTA. The Choroidal Vascularity Index (CVI) and OCTA vascular features at initial and last visit were analyzed after anti vascular endothelial growth factor (VEGF) treatment. These changes were correlated with the disease activity on SD-OCT and OCTA.
Results: Mean age was 66.34 ± 7.2 years. Mean sub foveal choroidal thickness was 215.39±102.378 µm at baseline and 198.42±101.049 µm at 3 months (p=0.07). The mean CVI was 63.73±5.28% at baseline & 64.59±4.87% at 3 months (p=0.754). Pattern of network on OCTA was sea-fan in 20(43.5%), medusa head in 8(17.4%), indistinct in 18(39.1%) at baseline and sea-fan in 6(13%), medusa head in 6(13%), indistinct in 28(60.9%) and mixed in 6(13%) at 3 months. The signs of activity on OCT changes after 3 months (p =0.001).On OCTA 36 eyes had active network at baseline & 34 eyes had inactive network at the last follow up (p=0.001).
Conclusion: Choroidal vascularity Index showed no correlation with various patterns of CNV and showed no significant change with anti VEGF treatment. Post treatment network patterns showed no significant correlation with the OCT activity even though the OCTA showed an active network.
Keyword :
OCT angiography, Choroidal neovascular activity, AMD.