Article type :

Original article

Author :

Soumyajyoti Kundu,Anil Kumar Dubey,Sisir Chakraborty,Pradip Kumar Sinha,Animesh Maiti,Swati Banerjee

Volume :

15

Issue :

1

Abstract :

Abstract Background & aims: Diabetic nephropathy is the leading cause of chronic kidney disease and end –stage renal disease. According to earlier studies serum folic acid and vitamin B12 were found to be reduced in such patients. Therefore, the present study was conducted to estimate and compare the serum folic acid and vitamin B12 values of diabetic mellitus patients with and without nephropathy. Materials and methods: A single institution based cross sectional study was conducted in Kolkata from March 2018 to September 2019.203 adult with at least five years history of type 2 diabetes mellitus were subdivided into two groups’ nephropathy and non-nephropathy. The cut off value for inclusion into nephropathy group was urinary albumin-creatinine ratio of more than equal to 30gm/dl. Serum folic acid and vitamin B12 values of both groups were estimated by Chemiluminescence assay and later statistically compared for result. Result: Overall 127 patients were grouped in non-nephropathy while rest 76 belonged to nephropathy. Both folic acid (4.68±3.64 versus 7.02±3.89; p