Abstract :
Background and Aims: Opioid-free anaesthesia (OFA) is an emerging approach in modern anaesthesiology aimed at reducing opioid consumption and its associated side effects. The combination of total intravenous anaesthesia (TIVA) with agents such as propofol, ketamine, and dexmedetomidine has shown promise in enhancing recovery while minimizing opioid use. This study aimed to compare the postoperative recovery time between two opioid-free total intravenous anaesthesia regimens, propofol-ketamine and propofol-dexmedetomidine, in patients undergoing routine surgical procedures.Methods: Sixty patients aged between 18-50 yrs, ASA I & II undergoing elective surgery of duration 1-4 hrs were randomly divided in two equal groups: group I propofol-ketamine and group II propofol-dexmedetomidine. Group I received ketamine 1mg/kg over 10 mins followed by 0.5mg/kg/hr. Group II received dexmedetomidine 1µg/kg over 10 mins followed by 0.5µg/kg/hr. Anaesthesia was induced by propofol 200µg/kg/min titrated to maintain BIS 40-60 and endotracheal intubation facilitated by rocuronium 0.6mg/kg. Hemodynamic parameters and BIS were recorded. Recovery time (modified Aldrete score), total propofol consumption, peri-operative complications, PONV, explicit recall, hallucinations and 24 hrs analgesic requirement were noted. Appropriate statistical tests were applied and p
Keyword :
Total intravenous anaesthesia, Opioid free anaesthesia, Ketamine, Dexmedetomidine, Modified Aldrete score, Postoperative recovery.