Abstract :
Background: Melasma is one of the most common causes of hyperpigmentation and is a prevalent cosmetic concern for patients. Tranexemic acid is an effective mode of treatment available in both oral and topical forms.
Aim: To evaluate and compare the therapeutic effectiveness of topical and oral tranexamic acid for the treatment of melasma.
Materials and Methods: A total of 84 patients who presented to dermatology OPD with melasma were divided into two groups, namely A and B. Group A patients were treated with oral tranexamic acid 250 mg twice daily, and patients in Group B were treated with topical 5% tranexamic acid with follow-up every 4 weeks until 3 months.
Results: Among the oral treatment and topical patient groups, a statistically significant difference in the mean percentage of reduction in MASI score from baseline was observed at 12 weeks (61.31±9.48 for oral vs 52.64±8.03 for topical) with p
Conclusion: Oral tranexamic acid gave a more promising result when compared to topical tranexamic acid. Despite having GI disturbances with oral tranexamic acid, it had more patient compliance and could be a promising therapeutic approach for melasma.
Keyword :
Melasma, Oral tranexamic acid, Topical tranexamic acid, Tranexemic acid, TA