Abstract :
Introduction: Oral submucous fibrosis (OSMF) is a scarring disease of the oral cavity that develops over time. Lycopene is a potent antioxidant found in tomatoes that has the best singlet oxygen quenching capability and a strong capacity to quench other free radicals in vitro of all the dietary carotenoids. A protein called hyaluronidase, which is found in mammalian sperm and testes, hydrolyzes hyaluronic acid to alter the permeability of connective tissue.
Objective: To determine the effectiveness of lycopene and lycopenehyaluronidase in treating OSMF, as well as a comparison of their effectiveness.
Materials and Methods : 45 people with OSMF were enrolled in the study and divided into three groups. Patients in Group A received two evenly divided doses of Lycored 16 mg twice daily for three months. Patients in Group B received LycoRed and a 1500 IU intralesional injection of hyaluronidase twice a week for three months. Patients in Group C received placebo pills. The patients were evaluated at the end of three months. We observed the opening of the mouth, visual examination, palpatory findings, and burning sensation.
Results: For lycopene and lycopene–hyaluronidase combination, there was a statistically significant difference in mouth opening and burning sensation compared to placebo.
Keyword :
Lycopene, Hyaluronidase, Oral Submucous Fibrosis