Abstract :
Introduction: Dermatophytosis is a superficial fungal infection of keratinized tissue. The infection is known as tinea. Various oral and topical antifungal agents used in clinicalpractice.
Objective: Comparative study between oral terbinafine and griseofulvin in dermatophytosis infection in children between 5 to 15 years
Methods: Patients of both gender and age between 5 to 15 years diagnosed as dermatophytic infection were enrolled for the study. Atotal of 100 patientswere divided into two groups. One group was treated with oral terbinafine and other withoral griseofulvin for 4 weeks. In addition a placebo cream/ lotion was applied locally.
Limitation: Large studies are required for more confirmation.
Conclusion: Oral terbinafine produced 88 percent cure while cure with griseofulvin was 72 percent .Clinical response to oral terbinafine was 16percentbetter.No significant adverse effects were noticed in either groups, except in some cases mild gastrointestinal disturbance.
Keyword :
Dermatophytosis, Terbinafine, Griseofulvin, Tinea, Fungicidal.