Abstract :
Background: Ovarian cancer represents 30% of all cancers of female genital tract. An accurate histopathological diagnosis of ovarian tumours is essential for their management and the outcome of therapy.
Aims and Objectives: Clinicopathological study of ovarian epithelial neoplasms and to study the expression of p53 and Her2/neu in epithelial carcinoma of ovary and their association with the histological grade.
Settings and Design: An observational descriptive type of study in a tertiary care hospital in Eastern India.
Materials and Methods: 72 cases diagnosed as ovarian epithelial neoplasms in the department of Pathology, CNMC&H Kolkata during the study period of January, 2019 to December, 2020 were studied. Specimens were processed routinely. Immunohistochemistry was done following standard protocol.
Statistical analysis: Statistical analysis was done using SPSS (version 21.0, Chicago inc., Chicago, Illinois, USA) software.
Results: 57 cases were benign followed by 14 malignant and 1 borderline case. Majority of the tumours were serous type (71.4%) followed by mucinous (27.2%) and seromucinous (1.4%). P53 expression was noted in 50% of the epithelial ovarian carcinoma and 85.7% of the high grade serous carcinoma. Her2/neu expression was noted in 21.4% of epithelial ovarian carcinoma cases.
Conclusion: p53 expression was more in serous carcinoma and the expression of p53 was associated with higher grade of serous carcinoma. Her2/neu expression was more in serous carcinoma. There was no significant association between Her2/neu expression and histological grade and a larger population based study is needed for further evaluation.
Keyword :
Ovarian epithelial neoplasms, Her2/neu expression, p53 expression in epithelial carcinoma of ovary.