Author :
Deepak Juyal, Shekhar Pal, Chitra Joshi, Abhay Kumar, Vineeta Gupta, Geetika Rana, Sonam Maheshwari, Swati Kohli, Himani Palariya, Deepak Juyal, Shekhar Pal, Chitra Joshi, Abhay Kumar, Vineeta Gupta, Geetika Rana, Sonam Maheshwari, Swati Kohli, Himani Palariya, Deepak Juyal, Shekhar Pal, Chitra Joshi, Abhay Kumar, Vineeta Gupta, Geetika Rana, Sonam Maheshwari, Swati Kohli, Himani Palariya
Volume :
12
Issue :
4
Abstract :
Background: Infertility, typically categorized, as primary or secondary infertility is a significant global health concern. Among the various contributing factors, sexually transmitted infections (STIs) play a major role. Notably, Chlamydia trachomatis and genital mycoplasmas, in addition to being common causes of STIs, are also strongly linked to infertility.Aim: We aimed to detect the presence of C.trachomatis and genital mycoplasmas among the patients seeking care for infertility. The association between infection and demographic parameters was also assessed.Materials and Methods: This cross-sectional study was conducted among the patients seeking care for infertility at the Obstetrics and Gynaecology, and Surgery Department OPD. From a total of 168 patients enrolled in the study, samples were collected which included endocervical/vaginal swabs from women and first void urine from men. Samples were subjected to semi-quantitative culture for Ureaplasma spp. and Mycoplasma hominis along with PCR assays targeting C.trachomatis, Ureaplasma parvum, U.urealyticum, M.hominis and M.genitalium.Results: Among the total 168 patients, C.trachomatis was detected in 20.8% patients. The presence of U.parvum, U.urealyticum, M.hominis and M.genitalium was observed in 9.5%, 3.0%, 7.1% and 3.6% of patients respectively. C.trachomatis co-infection with Ureaplasma spp. and Mycoplasma spp. was 38.1% and 38.9% respectively. Of clinical importance, the prevalence of C.trachomatis and genital mycoplasma infections was significantly higher among patients over 30 years of age.Conclusion: The detection of C.trachomatis and genital mycoplasmas among infertility patients highlights the need for routine screening of these pathogens as part of the standard diagnostic workup for infertility. Early and accurate diagnosis by using molecular techniques can prevent the infection transmission and associated complications including infertility.
Keyword :
Keywords: Adverse pregnancy outcomes, Mycoplasma spp., Pelvic inflammatory disease, Sexually transmitted infections, Tubal factor infertility, Ureaplasma spp.