Abstract :
Chitosan nanoparticles have expanded growing attention for Nano-medicine, development of new therapeutic and biomedical engineering with improved availability, increased specificity, and compact toxicity. The present study aim to synthesis and characterize inhalation of chitosan nanoparticles for antimycobacterial supply to the lungs. The ionic gelation method followed spray drying was used for chitosan nanoparticles development. The results showed that the obtained particles had a spherical smooth shape with an average size of 255 ± 3.5 nm. Post nebulization drugs were detected in numerous organs (lungs,
spleen and liver) till twenty four hours. A single dose of drug-loaded had a chemotherapeutic efficacy more effective against the mycobacterium than other available drugs.
Keyword :
Biosynthesis of chitosan nanoparticle, Mycobacterium Tuberculosis pulmonary drug.