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Article type :

Original Article

Author :

Monisha Basavaraju, M Raghavendra Rao, Ranjitha Shankare Gowda

Volume :

11

Issue :

1

Abstract :

Introduction: Multidrug and carbapenem resistance is an increasing problem worldwide, which are most commonly seen in Klebsiella and Acinetobacter in the health care setting. Due to this reason, the interest in older antimicrobial agent, like fosfomycin has increased. Acinetobacter species generally exhibit intrinsic resistance to fosfomycin, combining it with other antibiotics can often make it effective against these bacteria, particularly with multidrug-resistant strains, as fosfomycin can act synergistically with other agents to enhance its antibacterial activity. Aim and Objective: To detect the production of carbapenemases among carbapenem resistant (CR) Klebsiella and Acinetobacter spp. and also to know the susceptibility of CR A. baumannii and K. pnuemoniae to Fosfomycin. Materials and Methods: Prospective study conducted over a period of 1 year (Jan-Dec 2019) included 120 Clinical isolates of CR Acinetobacter baumanii and Klebsiella pneumoniae were collected from the patients admitted to a tertiary care hospital, Mysuru, Karnataka, South India. These isolates were subjected to a phenotypic method, the CARBA NP and CARB-ACINETO NP method for K. pnuemoniae and A. baumannii respectively to detect the carbapenemase production and also subjected to Fosfomycin susceptibility testing. Result: of the 57 CR A. baumannii, about 48(84.21%) were positive and 9(15.7%) were negative for CarbAcineto NP test method. And about 48(84.22%) were sensitive and 9(15.78%) were resistant to fosfomycin. Of the 63 CR K.pnuemoniae, about 50(79.63%) were positive and 13(20.63%) were negative for CARBA NP test method. And about 56(88.89%) were sensitive and 7(11.11%) were resistant to fosfomycin. Conclusion: Our study demonstrated high activity of Fosfomycin against CR A. baumannii and K. pnuemoniae representing that fosfomycin can be used as an important alternative to carbapenems and also to Colistin (i.e. in colistin resistant isolates).