Abstract :
Background and Objective: One of most important problems of dental composites refers to weakness of its antibacterial
activity and bacteria can grow on the surface of this composite which leads to secondary caries. The aim of this
study is to synthesize a derivative of pyrazole that called 3,5-dimethyl-1-thiocarboxamide pyrazole and its anti-bacterial
properties with its usage it to create anti-bacterial flowable dental composites.
Methods: Synthesis of 3,5-dimethyl-1-thiocarboxamide pyrazole by reaction between Thiosemicarbazide (tsc) and 2,4-
pentandione (Hacac) and antibacterial activity of this compound was evaluated by Agar diffusion method. Then it added
to flowable dental composite with 0-5 wt%. Also anti-bacterial properties of cured resin were studied by direct contact
and agar diffusion methods.
Results: According to our findings, 3,5-dimethyl-1-thiocarboxamide pyrazole has significant antibacterial effect against
Streptococcus mutans so that it has ability to make this property in flowable composites (p < 0.05).
Conclusion: Incorporation of 3,5-dimethyl-1-thiocarboxamide pyrazole into flowable resin composites can reduce
activity of Streptococcus mutans.
Keyword :
3,5-dimethyl-1-thiocarboxamide pyrazole, Antibacterials Activity, Dental Caries, Flowable Composites, Streptococcus mutans