Abstract :
Depression is one of the most common mental disorders which is classified in temper mood disorders. In traditional
medicine, ginger is used to increase memory and cure vomiting, bloating, indigestion, colic, and abdominal pain.
Current study was carried to compare ginger extract and imipramine effects on reducing depression symptoms.
Sixty mature mice in the weight range of 25 to 30g were divided into six groups: control, depression, imipramine,
and 50, 100, 200 mg/ml of ginger’s hydro alcoholic extract which was injected intraperitoneal. In the morning of
experiment, desired drug was injected and after 55 minutes, suspension test was carried out. Forced swimming and
tail suspension test was done One hour after suspension test. Immobility and mobility time was measured as
depression index. Obtained data were analyzed using SPSS program. In both tests, results showed that ginger
extract in 200 mg/kg doses increased mobility time and movement activity of animal significantly in proportion to
control and imipramine groups (p
Keyword :
ginger, depression, imipramine, laboratory mice