Abstract :
Glioblastoma multiforme (GBM) is an aggressive tumor that typically
exhibits treatment failure with high mortality rates, is associated with the
presence of cancer stem cells (CSCs) within the tumor. CSCs possess the
ability for perpetual self-renewal and proliferation, producing downstream
progenitor cells that drive tumor growth. Studies of many cancer types, have
identified CSCs using specific markers, but it is still unclear as to where in the
stem cell hierarchy these markers fall. This review examines the current
knowledge on the CSCs markers SALL4, OCT-4, SOX2, STAT3, NANOG,
c-Myc, KLF4, CD133, CD44, nestin, and glial fibrillary acidic protein,
specifically focusing on their use and validity in GBM research and how they
may be utilized for investigations into GBMs cancer biology
Keyword :
Glioblastoma multiforme, Cancer stem cells (CSCs), CSCs markers, Cancer biology