Abstract :
OBJECTIVE: To determine the frequency of raised C-reactive protein in patients with preeclampsia.
PATIENTS AND METHODS: This descriptive case series study of six months was conducted on Preeclamptic ladies at
Liaquat University Hospital Hyderabad. The inclusion criteria were pregnant women, ≥19 years of age, had third
trimester of gestation (28-40 weeks), diagnosed as had preeclampsia on the basis of clinical history & examination,
systolic blood pressure >140mmHg and diastolic blood pressure >90mmHg and had proteinuria. The relevant
preeclamptic ladies were further evaluated for serum C-reactive protein while the data was recorded on pre-designed
proforma and analyzed in SPSS 16. The frequency and percentage and mean ±SD was computed for study variables.
RESULTS: During six months study period total fifty patients with preeclampsia were evaluated for CRP. The mean ±SD
for age (years), gestational age (weeks) and CRP (mg/L) of whole population was 32.77±4.83, 33.76±4.62 and 22.82 ±
6.85. The C-reactive protein was raised in 33 (66%) participants and majority 24 (72.7%) were among 19-29 years of
maternal age and 28-29 (weeks) gestational age group 20 (60%).
CONCLUSION: Serum CRP levels was high in preeclamptic patients suggesting its role oxidative stress, inflammation
and considered as a diagnostic utility.
Keyword :
Preeclampsia, C-reactive protein and Acute phase protein.