Biochemical and haematological parameters predicting severity of Covid 19 infection: Lessons from first wave of pandemic


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Article type :

Original Article

Author :

Mrunal Kesari, Yoganand V Patil, Shweta D Agrawal*, Harshad V Kesari, Priyanka V Gadge, Lalita Y Patil, Haffizunissa Rehman

Volume :

8

Issue :

3

Abstract :

Context: Corona virus disease 2019 (COVID-19) was declared as pandemic by WHO on March 10, 2020. Several countries around the globe have seen a two-wave pattern of reported cases. India is witnessing unprecedented spike in COVID-19 cases again since March 2021 especially in Maharashtra. Newer insights in pathogenesis of diseases, diagnosis and treatment modalities continue to evolve in case of novel infection. Aim: To study and compare laboratory parameters in COVID cases in first wave in 2020. Design: Retrospective cross-sectional observational study. Materials and Methods: Total 400 cases; 354 RTPCR and 46 RAT confirmed cases of COVID-19 done at dedicated COVID Hospital. Statistical Analysis: Comparison of laboratory parameters was done between 72 Severe and 328 Non-Severe cases by unpaired t-test. Results: Statistically significant differences were seen in severe cases as compared to non severe cases in Lymphocyte count, Eosinophil count, Neutrophil Lymphocyte Ratio, CRP, D-dimer, Ferritin levels. WBC count, Platelet count and ALT did not show significant difference between severe and non severe cases. Conclusion: Lymphopenia, raised N/L ratio, Eosinopenia, increased D-dimer, Ferritin, CRP are associated with severe COVID disease. The routine laboratory tests can diagnose the disease, predict prognosis and complications and monitor treatment response.

Keyword :

COVID- 19, Laboratory parameters, RTPCR, Prognosis, Severe disease.
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