Abstract :
The study aimed to observe the association of Vitamin B12 and folic acid with thyroid hormones in healthy
pregnant women and pregnant women with Subclinical hypothyroidism. 68 healthy, age matched pregnant women
(controls) and 92 pregnant women with Subclinical hypothyroidism (cases) were included in the study. We have
observed significant positive correlation was observed between vitamin B12 and FT3 and vitamin B12 and FT4 in first
trimester. Significant positive correlation was observed between vitamin B12 and FT3 and significant negative
correlation was observed between vitamin B12 and FT4 in second trimester. Significant positive correlation was
observed between vitamin B12 and FT3 in third trimester. Significant positive correlation was observed between cord
blood vitamin B12 and FT3 of third trimester, significant negative correlation was observed between cord blood
vitamin B12 and TSH of third trimester in pregnant women with subclinical hypothyroidism
Keyword :
Pregnant women, Subclinical hypothyroidism, Vitamin B12, folic acid.