Abstract :
Background: Coronary artery disease is the most common and life threatening cardiac emergency
presenting to a hospital. Having significant mortality and morbidity are on the rise in Pakistan.
The objective of the study is to examine the association of elevated level of serum uric acid with
ischemic heart disease among adult population, to guide planning for primary and secondary
prevention of this disease in community.
Subjects and Methods: This cross-sectional study studied 110 consecutive patients from 20-80
years of age presenting with IHD (Myocardial infarction, unstable angina). All the subjects who
were approached to participate in the study, gave their consent. Face-to-face interviews were
conducted using a structured questionnaire followed by laboratory tests.
Results: Association of serum uric acid were lined up as gender, smoking, hypertension, diabetes
mellitus, menopause, dyslipidemia, family history and obesity. In this study, out of 110 patients
35 (32%) were females and 74 (68%) were males. Minimum Age of patients in this study was 30
years and maximum age was 70 years This study revealed that chest pain was the most occurring
symptom which was observed in 39 patients which are 35.45% of the total patients and the second
most occurring symptom was Dyspnea which was observed in 32 patients which 29.09% of the
total patients. The study reveals that the major risk factor observed in CAD patients is ‘HTN’
which was found in 81 patients which are 73.64% of the total patients. However, ‘Smoking’ and
‘DM’ are proximate in occurrence and were found in 59 (53.64%) and 56 (50.91%) patients
respectively. The study revealed that hyperuricemia was more in males that was 34(22.67) than in
females.
Conclusion: This study concluded that there was no significant association between
hyperuricemia with ischemic heart disease.
Keyword :
Ischemic heart disease, Serum Uric acid