Abstract :
Diabetic nephropathy accounts for the most serious microvascular
complication of diabetes mellitus. It is suggested that the prevalence of
diabetic nephropathy will continue to increase in future pretense a major
challenge to the healthcare system resulting in increased morbidity and
mortality. It occurs as a result of interaction between both genetic and
environmental factors in individuals with T2DM-Type 2 diabetes
mellitus. Genetic susceptibility has been offered as an important factor for
the development of diabetic nephropathy, and various research efforts are
being executed worldwide to identify the susceptibility gene for diabetic
nephropathy. Several single nucleotide polymorphisms have been found
in various genes giving rise to various gene variants which have been found to play a role in genetic susceptibility to
diabetic nephropathy. The risk of developing diabetic nephropathy is increased several times by inheriting risk alleles
at susceptibility loci of various genes like ACE, GST, TNF-α, COL4A1, eNOS, GLUT, etc. The identification of these
genetic variants at a biomarker level could thus, let the detection of those individuals at high risk for diabetic
nephropathy which could thus help in the treatment, diagnosis and early prevention of the disease. The present review
discusses about the ACE-Angiotensin Converting Enzymeand GST-Glutathione S Transferase gene variants
associated with diabetic nephropathy.
Keyword :
Syed Tasleem Raza, Ale Eba, Sachendra P. Singh, Syed Tahseen Raza*, Farzana Mahdi