Abstract :
Background: Diabetes mellitus & thyroid dysfunction are the most common endocrinological disorders in the current era. Diabetes mellitus is a group of metabolic disorders usually associated with dyslipidemia which increases risk of cardiovascular disorders and resultant morbidity & mortality. Thyroid dysfunction particularly hypothyroidism is frequently encountered in diabetic patients. T2DM results in reduction in thyroid releasing hormone (TRH) synthesis & limits T3 & T4 production, which results in increased total cholesterol & LDL in circulation. By studying the association of thyroid hormones & lipid profile in diabetes patients, we can enhance the knowledge about the interrelation between diabetes, thyroid
hormones & dyslipidemia.
Aim: To study the association between thyroid hormones & lipid profile in Type 2 Diabetes Mellitus patients.
Methodology: This is a case control study comprising of 50 cases (T2DM) & 50 age & sex matched healthy controls. Fasting blood sample was taken and analysed for blood sugar, lipid profile, Triiodothyronine(T3), Thyroxine(T4) & TSH.
Results: In this study, higher serum level of total cholesterol, LDL-cholesterol & triglycerides seen in T2DM patients. Also significantly lower T3&T4 and higher TSH are observed in T2DM. Moreover, there was a significant positive correlation between TSH and TC, LDL-C and TGL & significant negative correlation between T3&T4 and TC, LDL-C & TGL.
Conclusion: Thyroid dysfunction is associated with lipid dysregulation in T2DM patients. Early & routine screening of thyroid disorders in T2DM patients can reduce morbidity due to dyslipidemia.
Keyword :
Dyslipidemia, T2DM, Thyroid hormones.