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Article type :

Original Article

Author :

Emmanuel Chukwuemeka Ogbodo*, Christian Ejike Onah, Akuma Kalu Amah, Chinenye Stellamaris Okeke, Maryrose Oluchukwu Obiorah, Alozie Ogwuegbu Okezie, Romanus Ogai Ogalagu, Joy Chidinma Iwuji, Raphael Emmanuel Mbam, Samuel Chukwuemeka Meludu

Volume :

11

Issue :

2

Abstract :

Background and Aim: Biochemical changes in glycemic indices have been linked to aging, and many individuals have asymptomatic hyperglycemia as they get older. This leads to metabolic dysregulation, which heightens vulnerability to a number of age-related chronic conditions, such as diabetes mellitus. Materials and Methods: This cross-sectional study assessed the levels of fasting plasmanglucose, insulin, insulin resistance and glycated haemoglobin as markers of glycemic control in apparently healthy older adults in Nnewi. A total of 144 participants were involved in this study: 72 older persons and 72 control subjects. The older adults were aged 45 to 75; while the control group was composed of individuals aged 18 to 30. Six milliliters (6 ml) of fasting venous blood samples were collected from each participant for the determination of insulin (INS), glycated haemoglobin (HbA1c), and plasma glucose (FPG) levels. Enzymelinked immunosorbent assay was used to evaluate INS, resin ion-exchange was used to estimate HbA1c, and glucose oxidase peroxidase was used to determine FPG. The Homeostasis Model Assessment Index (HOMA-IR) was used to calculate insulin resistance. Results: The mean FPG, HbA1c, INS and HOMA-IR were significantly higher in the older adults compared to control subjects respectively (p