Abstract :
Aims & Objectives: Study of the hematological and coagulation parameters in cytologically diagnosed cases of tuberculous lymphadenopathy.
Materials and Methods: A cross sectional study of 60 newly diagnosed cases of tuberculosis on cytology was done. Venous blood samples were collected in EDTA and Citrate vacutainers. XN 1000 fully automated hematology analyzer and Vesmatic were used for hematology parameters and ESR respectively. Stago analyzer was used for coagulation studies. Hematological and coagulation parameters were studied and were analyzed using t test with significance level of 5%.
Results: 60 cases presenting with tuberculous lymphadenopathy on cytology were analyzed which showed a M: F of 1.2 :1. Anemia was noted equally in both sexes. ESR and WBC count was raised in 92% and 45% of cases respectively. Prothrombin Time was raised in 87% of cases while Activated Partial Thromboplastin Time was raised in 45% of cases. Platelet count was normal in 88% of cases. Lymphocytosis was noted in 85% of cases while 52% cases revealed neutrophilia. Smoking and literacy rate had positive correlation. Paired t test shows positive correlation between age and WBC count (p Discussion & Conclusion: Tuberculosis is a hypercoagulable state with alteration in the hematological profile. These simple blood tests with no additional cost can serve as guide to physicians in establishing the early diagnosis along with clinical findings and ancillary investigations. Such Pilot studies can be extended to larger populations and corporate setups to start early treatment and reduce the morbidity and mortality.
Keyword :
Tuberculosis, Cytology, Anemia, Coagulation, Industrial Population