Abstract :
Aripiprazole and Clozapine are classified as an Atypical Antipsychotics.
Aripiprazole primarily used in the treatment of schizophrenia and bipolar
disorder. Clozapine works by changing the actions of chemicals in the
brain. It is used to treat severe schizophrenia, or to reduce the risk of
suicidal behavior in people with schizophrenia or similar disorders. It is
also used in Parkinson’s disease. The clinical and pharmaceutical analysis
of these drugs requires effective analytical procedures for quality control
and pharmacodyna44mic and pharmacokinetic studies as well as stability
study. There are many analytical methods reported so far in the literature
for the determination of Aripiprazole and Clozapine in Biological samples
and pharmaceutical formulations. This article comprises reviews of
analytical methods like Spectrophotometric methods, chromatographic
methods.
Keyword :
Aripiprazole, Clozapine, Spectrophotometry, HPLC