Abstract :
Poor bioavailability is one among major challenges faced by the pharmaceutical drugs in the dosage form development. Atorvastatin (AST) is one among such challenging drugs facing poor bioavailability due to poor solubility. The objective of this article is to review the literature published in the selected search engines about the solubility / bioavailability enhancement of AST. Literature was searched in the four databases Science direct, PubMed, Google scholar, and BASE engine. Seventy-one articles related to atorvastatin formulations were selected from which 26 articles related to bioavailability enhancement were discussed. Further, various method of estimation of AST alone and in formulations were also compiled. Results: researches that the bioavailability could be improved by several methods including solid-dispersion co-crystallization, Microspheres, solid lipid nanoparticles, co-solvency, and nanosuspension, self-nano emulsifying drug delivery system (SNEEDS). Further, simple UV and HPLC methods could be used for the estimation of AST alone and in combination.
Keyword :
Solid dispersion, Nano emulsion, solid-lipid nano-particles, Co-solvency.