Abstract :
The present study was initiated to develop colon targeted enteric-coated matrix tablets of Vancomycin HCl
500 mg by incorporating chitosan-based polyelectrolyte complex (PEC). The matrix tablets were development
and optimized using 32-full factorial design. The Vancomycin HCl is an antimicrobial substance used in the
treatment of enterocolitis. Hence, localization of the drug at its site of action is more useful. The pharmacokinetic
parameters of drug also offer feasibility for colon-specific drug delivery and were developed with a view to have
lag time 4–6 h, controlled release in the colon over a period of 16–20 h. The optimized formulation showed
10% drug release during lag time, 98% at 20 h, and the study of antibacterial activity for the developed best
formulation indicating effective killing of Staphylococcus aureus. The study was carried out to check the ability
of PEC to release the Vancomycin HCl in the presence of rat cecal content medium resembling the physiological
environment of colon.
Keyword :
Anti-bacterial studies, enteric coating, ex vivo studies, lag time, optimization, polyelectrolyte complex, Vancomycin HCl