Volume :
1
Issue :
2
Abstract :
The extract of Crataeva magna was screened for antinephrolithiatic activity in male Wistar rats were summarized based on the ionic changes in both Urine & Serum. The present study was carried out to evaluate Antinephrolithiatic activity in rats using 0.75% ethylene glycol in drinking water was given orally for 28 days. The plant Crataeva magna is used in analgesic, anti protozoal, hypoglycemic, anti inflammatory, hypotensive, anti spasmodic purposes. The aqueous extract of leaves of Crataeva magna results maximum yield value than that of petroleum ether extract, chloroform extract and alcohol extract through successive maceration process. The aqueous extract of leaves of Crataeva magna showed maximum control of lithiasis in Wistar rats. Urinary risk factors of urolithiasis were monitored at the end of 7th, 14th, 21st, and 28th days. Urinary volume was increased in nephrolithiatic as well as drug-treated rats. Increased urinary excretion of Calcium, Oxalate, Uric acid, Phosphorus and Protein in nephrolithiatic rats was brought down significantly by the administration of Crataeva Magna. Decreased magnesium excretion in hyperoxaluric rats was normalized with respect to calcium oxalate and other crystallizing salts such as uric acid, which may induce epitaxial deposition of calcium oxalate. Simultaneous treatment with the extract reduced Calcium and Oxalate ion concentration in Urine confirming the stone inhibitory effect. In Ethylene glycol induced nephrolithiasis, the nephrolithiasis was significantly reduced and the stone formation was normalized by administration of 200 mg/kg and 400 mg/kg dose orally and the property was comparable to the standard drug. This study has established the antinephrolithiatic activity of Crataeva magna and thus, justifies the uses of this plant for lithiasis.