Abstract :
Commiphora molmol is one of the plants that have been treasured since ancient times due to their effective
applications in traditional medicine. The aim of this investigation was to evaluate the effect of C. molmol on mice
infected with E. coli O157 with special reference to antibody production and histopathological changes. C. molmol
water extract showed high antibacterial activity in vitro when compared with the hindrance activity of the reference
antibiotic ciprofloxacin disk (CIP5) 5µg/ml. In vivo experimental study revealed that E. coli O157 count significantly
decreased while Antibody titer detected by ELISA showed a trend to decrease in infected mice following the
administration of C. molmol water extract. Histopathological findings showed the presence of less degenerative
changes following the administration of C. molmol water extract. These findings revealed that C. molmol plant
induced suppression to E. coli O157 infection and indicated the possibility of using C. molmol water extract as natural
and safe alternative to synthetic antibiotics to control E. coli O157 infection.
Keyword :
Commiphora molmol, Antimicrobial activity, Antibody production, Histopathological changes, E. coli O157.