Abstract :
Quorum sensing (QS) is a bacterial cell to cell communication, which helps bacteria to mount population-densitydependent
infection to overcome the defence responses from host. In this mechanism some diffusible chemical
signalling compounds are involved, known as autoinducers, which are directly proportional to the population cell
density. The main role of QS is to coordinate the expression of several collective traits, including the production of
virulence factors, secondary metabolites with antimicrobial activity, pigment production, siderophore production,
epiphytic fitness, bioluminescence, plasmid transfer, motility and biofilm formation. Due to the growing bacterial
resistance to the antibiotics that have been overused, it has become necessary to search for alternative antimicrobial
therapies. One of them is anti-quorum sensing agents/anti-biofilm agents/quorum sensing inhibitors that disrupts the
bacterial communication. This study discusses the various QS-disrupting mechanisms used by anti-quorum sensing
agents such as, inhibition of AIs synthesis inhibition of AI transport, degradation of AIs using enzymes, sequestration
of AIs using monoclonal antibodies, QS signal competition (QS mimicry), as well as the different techniques applied
artificially to inhibit the QS pathways in bacteria and thus protecting plant from bacterial diseases.
Keyword :
Autoinducers, Biofilm and Quorum sensing