Abstract :
Leukemia is a gathering of malignancy began from bone marrow and will deliver impact on white platelet which will thus lead to anomaly. Presently the development of impact will continue by the undeveloped and juvenile WBC. Leukemia is an expansive term covering a range of infections. The focal point of enthusiasm for oncology especially in leukemia vitamin C has the best technique by which it demonstrates the more noteworthy outcome. An undeveloped cell takes amazingly elevated amounts of Ascorbic acid, which at that point allot their capacity and subdue the improvement of leukemia. Vitamin C levels manage HSC numbers and capacity. At the point when ascorbate levels are reduced, it can give the power to the deactivation of a catalyst called Tet2. The inactivation of TET2 is represented by change and insufficiency of vitamin C may constrain Tet2 work in tissues in a way that builds the danger of leukemia. TET2 function is actually strengthen by ascorbate level. By encouraging DNA demethylation, tremendous dose of ascorbate treatment can persuade stem cells to develop and the growth of cancerous stem cells will retarded by the tremendous dose of ascorbate level as investigated in mice. Tremendous dose of ascorbate might become a safe treatment for blood diseases caused by TET2 deficient leukemia stem cells, most likely in combination with other targeted therapies. Tarun Gupta | Virendra Kumar Vishwakarma | Manoj Kumar Maurya | Khushdil Khan "Anti-cancer Activity of Vitamin-C Against Leukemia: A Review" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-4 , June 2018, URL: https://www.ijtsrd.com/papers/ijtsrd14250.pdf Paper URL: http://www.ijtsrd.com/biological-science/biotechnology/14250/anti-cancer-activity-of-vitamin-c-against-leukemia-a-review/tarun-gupta
Keyword :
Leukemia, Blast cells, Vitamin-C, Tet2, DNA Methylation