Abstract :
Microbiota are present in biofilms, which are highly structured and complex entities that are radically different from microbes in planktonic suspensions. Biofilms cause root canal infections. The root canal system’s complexity and variability, combined with the multi-species presence of biofilms, make disinfection extremely difficult. The most critical reason for root canal treatment failure tends to be microbial persistence, which may have an effect on pain and quality of life.
In biomedical science, pathogenic microorganisms and their chronic pathogenicity are major concerns. Because of the prevalence of multidrug-resistant microbes in biofilms, chronic infections are difficult to treat. Researchers are searching for many effective natural anti-biofilm agents due to the low efficacy of various drugs and the in vivo toxicity of available antibiotics.
Rural extracts and natural product-based anti-biofilm agents are more effective and have less side effects than their chemically synthesised counterparts. The current review focuses on various natural anti-biofilm agents, such as phytochemicals, biosurfactants, antimicrobial peptides, and microbial enzymes, as well as their origins, mechanism of action through interfering in the quorum-sensing pathway, and mechanism of action via interfering in the quorum-sensing pathway.
Keyword :
Biofilm, Quorum sensing, Anti biofim agent.