Abstract :
Background: Tuberculosis (TB) is the most prevalent health disorder in developing nations and is linked with decreased immunity. Vitamin D is one of the most important vitamins required to boost immune response as it is required to maintain innate immune response via its actions on TLRs and macrophages. Risk of Tuberculosis has been associated with decrease level of vitamin D in serum in various studies. Despite of these studies some discrepancies have been shown in different studies conducted in different regions which further potentiates the role of various factors like diet, ethnicity, and seasonal variations
influencing the prevalence of T.B in vitamin D deficient and non-deficient population. This study has been conducted to evaluate and establish the link of serum vitamin D in TB and non TB population residing in Mathura region of U.P.
Materials and Methods: Total studied population was 80. 40 participants were taken in patient group with newly diagnosed Tuberculosis both pulmonary and extrapulmonary and 40 were enrolled in healthy control group. Serum sample was collected twice first before the start of treatment in patient group and then after the three months of effective treatment initiation.
Results: Among the two groups i.e., control and patient serum level of vitamin D in patient group was found to be significantly low as compared to the control group (22.66±15.17 vs73.03±25.6 ng/mL: P?0.68.
Conclusions: Healthy population has higher serum levels of vitamin D as compared to patients with tuberculosis.
Keyword :
Chemokines, Interferon-gamma, Vitamin D, Tuberculosis.