Volume :

2

Issue :

4

Abstract :

Researchers have explored a diversity of clinical and laboratory tests in efforts to differentiate Parkinson’s disease patients from a healthy population multi factorial disease known to result from a variety of factors. Age is the principal risk factor; other etiological mechanisms have been identified, including gene mutations and exposure to toxins. Deregulation of energy metabolism, mostly through the loss of complex I efficiency, is involved in disease progression in both the genetic and sporadic forms of the disease. In support to data analysis, a mathematical model of the relevant metabolic pathways was developed and calibrated onto experimental data. Diagnosis of Parkinson disease (PD) and risk factors or early symptoms amenable to population-based screening, systematic review and meta-analysis of risk factors for Parkinson’s disease.