Volume :
2
Issue :
4
Abstract :
Administration of drugs through oral route is the most preferable route of drug delivery as it is simple, easy to administer and have greater patient compliance. But its advantages have become limited in case of drugs with low absorption window. There has been considerable research over the past few years on the possibility of controlled and site specific delivery to the GIT by controlling the gastrointestinal transit of orally administered dosage forms using gastroretentive drug delivery system (GRDDS). A wide range of dosage forms have been developed for the drugs which have narrow absorption window, stability and solubility issues at GI pH, and having stomach as a site of action. The present review briefly describe the gastro retentive drug delivery (GRDD), various approaches for GRDDS, factors controlling gastric retention, merits, demerits and applications of gastroretentive drug delivery systems.