An observational study on the effectiveness & safety of anti-glaucoma medications in treatment naive patients of primary open angle glaucoma


Article PDF :

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Article type :

Original Article

Author :

Aditi Maitra, Shashwat Bhattacharyya, Kumaresh Chandra Sarkar, Shatavisha Mukherjee, Sambuddha Ghosh, Santanu Kumar Tripathi

Volume :

11

Issue :

1

Abstract :

Background: The paradox of open angle glaucoma therapy lies in the loss of reported efficacy of drugs when they are studied for real world effectiveness. Studies related to effectiveness and safety done in a longitudinal fashion in new cases of open angle glaucoma are scant. This study was undertaken to address the shortcomings in this regard. Materials and Methods: This was an open label, prospective, observational study. The patients were taken up for the study at their baseline visit and 3 subsequent follow up visits for next 6 months. The effectiveness was gauged on the basis of average IOP changes from baseline. Each patient was administered questionnaires for ocular surface disease and interviewed for possible adverse drug reactions at each follow up. Results: There were 68 participants who completed the study. All these patients reported at baseline and 3 subsequent follow ups. The mean baseline IOP was 27.20 (SD 6.29) mm of Hg and this reduced considerably to 16.97 mm of Hg (SD 3.18) which was a 37.61% reduction from the baseline (p

Keyword :

 safety, Antiglaucoma drugs, Effectiveness, Ocular surface, Prostaglandin analogs.
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