Abstract :
Anxiety disorder is a chronic psychiatric condition associated with increased morbidity and mortality,
personal distress and reduced quality of life. Currently used anxiolytic drugs only have modest efficacy
and are associated with significant untoward effects which leads to low compliance.
Traditional ayurvedic medicine describes Garcinia indica as a home remedy for many conditions.
Hydroxycitric acid, a phytochemical constituent of Garcinia indica, has shown to elevate brain serotonin
levels in the rat. The main aim of the present study is to evaluate the anxiolytic activity of Garcinia indica
fruit rind in preclinical models.
Materials and Methods: Male and female wistar albino rats were divided into four groups with six
animals in each group: Control(0.1% carboxymethylcellulose 10ml/kg), Garcinia indica ethanolic extract
(GIEE1- 200mg/kg), Garcinia indica ethanolic extract (GIEE2- 400mg/kg) and Diazepam (1mg/kg). All
the drugs were administered orally for a period of 14 days. On the 14th day after one hour of drug
administration, animals were evaluated using two models- Elevated plus maze and Light dark arena.
Statistical analysis: Statistical significance was interpreted using one way ANOVA (Analysis of Variance)
followed by Tukey Krammer Test.
Results: GIEE1 and GIEE2 treated groups showed significant increase in time spent in open arms and time
spent in light arena in elevated plus maze and light dark arena model respectively, compared to control.
Conclusion: Garcinia indica ethanolic extract demonstrated significant anxiolytic activity compared to the
control.
Keyword :
Anxiolytic, Garcinia indica, Fruit rind, Preclinical models.