Abstract :
Objectives: Hepatotoxicity occurs as a side effect of first line anti-tubercular drug such as Isoniazid. The aim of the present study was to evaluate therapeutic potential of ethanolic extract of Rosa damascene flowers (RDEE) in isoniazid induced hepatotoxicity in rats.
Methods: Rats were given orally isoniazid (50 mg/kg) for 28 days. Silymarin (50 mg/kg) was administered, as standard drug. From 29th to 43rd day of the study, isoniazid was stopped and therapeutic agents such as normal saline, silymarin, RDEE 1.5g/kg and 3g/kg were given orally in different animal groups respectively. On 44th day, blood samples were collected for biochemical analysis and liver tissue was subjected to histopathological examination.
Results: The rats administered RDEE showed significant reduction in the liver marker enzymes and total bilirubin treated as compared to negative control group. There was also significant improvement in antioxidant levels and histopathological scores in RDEE treated group in comparison to the negative control group.
Conclusion: This study demonstrates the beneficial effect of ethanolic extract of Rosa damascene flowers (RDEE) as a therapeutic agent in hepatotoxicity induced by isoniazid in a dose dependant manner.
Keyword :
Rosa damascene, Hepatoprotective, Isoniazid, Silymarin, Tuberculosis, Hepatotoxicity.