Abstract :
Aims: To study the clinico-pathological features of acute leukemia as second malignancy in primary solid
cancer after conventional treatment.
Objectives: To study and compare the demographics, treatment and prognosis of acute leukemia and solid
cancer as second malignancy.
Materials and Methods: It’s a retrospective study conducted over period of nine years in our centre using
computer based data base and medical records as the data source from the department of medical oncology
and hematology.
Result: Total 17 patients were diagnosed with primary solid cancers who underwent conventional treatment
including surgery, chemotherapy and/or radiation. Majority of cases were female patient (64.7%) with mean
age of 58 years (range 39-96yrs) diagnosed as primary solid cancer with stage 3 (52.94%). With stage2
(41.17%). Out of 17 patients, only 4 patients (23.5%) developed acute leukemias which included 3 AML
and 1ALL. Of these four patients, only one could be salvaged for about a year with allogenic transplantation
while rest three died within a month in an average.
Conclusion: Acute leukemias are one of the worst second malignancies that might occur after conventional
treatment in solid cancers which should be regularly monitored during the follow up period.
Keyword :
Acute leukemia, Solid cancer, Treatment.