Volume :
2
Issue :
2
Abstract :
The present study was to establish Bi-layer tablets containing Metformin hydrochloride as extended release layer and Glibenclamide as immediate release layer for the treatment of type II diabetes mellitus. Extended release layer was prepared by wet granulation method using HPMC 100 and ethyl cellulose as polymers. Immediate release layer were prepared by using super disintegrants such as sodium starch glycolate and cross carmellose sodium. The granules were evaluated for bulk density,tapped density, compressibility index,and hausner’s ratio. The granules showed satisfactory flow properties. The tablets were subjected to weight variation test, hardness test, friability test, drug content test ,wetting time and water absorption test. All the tablets were passed the tests. The in-vitro release studies were carried out in phosphate buffer of PH 6.8 for 12 hours using USP-type II paddle apparatus. The in-vitro release profiles of drug from sustained release layer could be best expressed by Higuchi’s equation as plots showed high linearity (R2> 0.988). The formulations (F12, F27) having immediate release layer produces effect within 30 minutes followed by sustained release (98.90%) at 12 hours.